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and endocrinologists as the mastic gland and its hormones, were known as regulators of crossed outsuchcrossed out ^other glands ^'such' as the thyroid. ^'Little was known about' its action upon the adrenal cortex crossed outwas not knowncrossed out until the nineteen twenties when it was noted that experimental animals which had been deprived of their pituitary glands were unable to withstand stress. The animal used was the rat and the form of stress applied was cold. The results were conclusive, and were further supported by the converse experiment in which hypo physcetomized animals were found to recover their power to withstand stress by the administration of a crude water extract of pituitary tissue. It was then the task of bio-chemists to break down that crude extract into its various protein constituents and identify the fraction associated with the withstanding of stress. Out of these patients and crucial labors there ^'finally' emerged the adrenocothicohophic hormone (ACJH) complete with the molecular weight and