.MTM5Ng.MTIwNjY2

reagents.

    When the control data were complete Betty

was given her first intramuscular injection of adrenocorticotrophic hormone and the experimental period was written for 48 hours and a total of 200 mgs. of the material.

   At the end of the first experimental day

our patient was considerably worse. She had retained most of the fluids she had taken in crossed out: and showed an ^'overall' gain in weight of 3½ lbs, & her poor little face was more bloated and disfigured than ever. This was not entirely unexpected since, according to my theory, I was giving a powerful dose of a substance which was already present in excess. But for me it was hard to bear. Hard to bear also were the cold faces of the nurses. I struggled to maintain a ^'semblance of' scientific objectivity, and we continued our rounds without much discussion.

   Twenty-four hours later, the edema

had continued to increase and we found ourselves surrounded by now turned sullen faces as we