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Please keep me in close touch with results as they begin to come in, and don't hesitate to let me know if I can be of service. Best of luck!"

   In the hospital at that time was a 19-year old

white girl named Betty who was all that the most impersonal researcher could ask as a typical example of long-standing glomerulonephritis, with ^'20-30 lbs edema, which was refractory to all attempts to produce a diuresis. I spent an hour with the house staff going over the records of her several hospitalizations, and explained the purposes of the experiment and the procedure to be followed. Betty herself was then invited to sit in on the meeting and asked if she had any objection to being the first sufferer from nephritis to be treated with ACTH. She assured us she had none and only wanted to know if she could be allowed to keep the vials as souvenirs. We crossed out: then listed the data to be collected, crossed out: and wrote the orders for the nurses and then went to my laboratory to alert the technicians and check on all the