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of Friday function, learned in Indianapolis and subsequently practiced in a wide variety of cases, had contributed new facts and suggested new insights into the pathogeneses of glomonulonephritis. Reviewing also the facts concerning the excretion of sodium and chloride in cirrhosis and in cardiac decompensation as they had become clear to me through the good offices of the edematous alcoholics on the wards of the County Hospital, I came to the tentative conclusion that Bright's Disease was not at all as the conventional teachings dictated, that far from crossed outbeingcrossed out ^'presenting' the picture of kidneys which were unable to excrete, it reflected renal tubules reacting to abnormal climate by salt - and water-retaining , hormones ^'hence working findings of such hormones, only those elaborated by the adrenal cortex were capable of producing the rates of ^'urinary' sodium to chloride demonstrated to exist in glomerulonephritis with edema. Drawing the conclusions, the disorder would have to be interpreted not as an organ disease but as an