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reagents.

When the control data was complete Betty was given her first intra muscular injection of adrenocorticotrophic hormone and the experimental period was written for 48 hours and a total of 200 mgs. of the material.

At the end of the first experimental day our patient was considerably worse. She had retained most of the fluids she had taken in crossed outandcrossed out showed a ^'overall' gain in weight of 3 1/4 lbs, & her poor little face was more bloated and disfigured than ever. This was not entirely unexpected since, according to my theory, I was giving a powerful dose of a substance which was already present in excess. But for me it was hard to bear. Hard to bear also were the cold faces of the nurses. I struggled to maintain a ^'semblance' of scientific objectivity, and we continued our rounds without much discussion.

Twenty-four hours later, the edema had continued to increase and we found ourselves surrounded by now more sullen faces as we