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other chemical characteristics and crossed outreadycrossed out reproductible on an enlarged scale by the big commercial laboratories. Since the material was a protein and its manufacture therefore depended upon a process of extraction, not of ^'chemical' syntheses, it was logical that the commercial production should be undertaken by one of the great packing houses such as Armours. By 1945-49, the new "wonder drug" was being made at rather enormous cost in smallish lots which were rather less uniform in their physiological action than would have been desirable. Even so, Armour Laboratories planned to devote a year to the clinical trials which would determine the physiological action and hence the potential usefulness of ALH as a therapeutic agent.

Almost all of this background ^'information' was unknown to me when I looked up the number of Armour Laboratories in the telephone directory, dialed and asked for the person in charge of the ACTH project. In touch with Dr. John R Mote I explained that