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arm. I wondered what "studies" we would perform that would reveal the mechanism of hypertension in those appalling cases in which the blood pressure suddenly rises relentlessly and the arteries seem to kindle and smoulder, searing the tissues which they supply. Merely a routine "work-up" did not seem to me to have much value, and after a few days spent mostly in the medical library looking up the literature on the toxemias of late pregnancy, I was so despondent that the whole project began to look to me like a piece of audacious nonsense. Nevertheless I prepared a card-index of abstracts covering all the work done in the toxemias over the preceding ten years and waited for a chance to talk with Dr. C. In the meantime, it became clear to me that there were two possible approaches to the problem, the first being the brilliant idea, the shot in the dark, if anyone of us could come up with it in which case the method would be therapeutic. I've the right hormone, for example, and demonstrate its correctness by the beneficial results. The other