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possibility was the adoption of much more sensitive and advanced tests in the hope that a consistent defect might show up which could be correlated with the clinical course. In the end we followed both approaches, and I drove around the city giving large amounts of if I remember correctly-corpus luteum hormone to see whether the patients got better or at least didn't get worse. It was a cumbersome example of a poorly controlled experiment which was not without its damages, in that we were hopeful enough about our corpus luteum to prevent the obstetricians from interrupting the pregnancy, the procedure which was clearly indicated. The second approach, calling for more sophisticated tests, was also tried, and I was sent to the laboratory of Dr. Irvine Page, at that time in Indianapolis to learn how to set up the insulin clearance test of renal filtration rate which was to provide us with useful and reportable date even though it might not reveal the pathogenesis of hypertension. With the