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If Joseph's disease be a unclear of unclear nerves of the spinal column which could unclear the nerves of motion, and if so unclear that nature's efforts cannot repair the break, then it seems to me there is no hope that he will regain the use of his limbs, but it must gradually affect all the nerves of voluntary motion and render him nearly helpless. O' what a terrible affliction any unclearunclear! How will he bear it? The grace of God only can enable him. 'Affliction' sparing not from the dust some wise purpose is to be answered!- Joseph when a child as I distinctly remember was a very mild, gentle, and loving, and rather remarkable for a sweet and confiding disposition. In the later? years of his manhood I have sometimes sighed at the apparent change in him (I mean only a lack of the unclear, communicative spirit of his boyhood). Could perhaps by buffering the cold, calculating, selfish world?, steeling the mind, repressing its finer sensibilities, or as he expressed it, "toughening? the feelings?" The stern force of circumstances modify the character much; they form the root of the great unclear to